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Home Thalassaemia

Thalassaemia

The Biography

David J. Weatherall
Hematology - general, History of medicine
Book
  • Thalassaemia - 9780199565603
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Content
The first exploration of the history of the disease, written by a world authority in the area Explores the story and background to the disease and the development of research into its genetic implications A fascinating account of the growing scientific understanding and changing attitudes towards the most common genetic disorder Examines the improvements in the control and management of the disease, and new treatments Thalassaemia is the most common type of genetic disorder in the human population, and one of the first whose genetic basis was established. Written by Sir David Weatherall, an expert in molecular medicine and the founder of the Institute of Molecular Medicine in Oxford, this tells the story of early reports of the disease, historical accounts, the identification of the disease as having an inherited basis, early work on thalassaemia as a disorder of the synthesis of haemoglobin, and from the 1960s with the rise of molecular biology, the study of the condition at the DNA level. The commonality of the disease raised an important evolutionary question: if thalassaemia is a genetic disorder then why hasn't it been selected out? Why does it persist, especially in Mediterranean populations? The great geneticist JBS Haldane suggested a reason - that carriers might be more resistant to malaria. Now that we have much more detailed understanding of the molecular basis of this set of diseases, has Haldane proved to be right? Weatherall shows that Haldane turns out to have been partially right. The book ends with recent improvements in treatment that have transformed patients' lives and a general assessment of how molecular approaches are impacting on medicine. Thalassaemia: the biography is part of the Oxford series, Biographies of Disease, edited by William and Helen Bynum. In each individual volume an expert historian of medicine tells the story of a particular disease or condition throughout history - not only in terms of growing medical understanding of its nature and cure, but also shifting social and cultural attitudes, and changes in the meaning of the name of the disease itself. David Weatherall , Founder of the Institute of Molecular Medicine in Oxford CONTENTS Prologue 1: Beginnings: 1920 - 1935 2: Thalassaemia is an extremely common genetic disease: 1935 - 1950 3: Thalassaemia as a genetic disorder of haemoglobin production: 1950 - 1960 4: Defective haemoglobin synthesis in thalassaemia and speculations about its molecular basis: 1960 - 1974 5: The molecular era and the birth of molecular medicine: 1975 - 2000 6: Was Haldane right? 7: Lessons for the biomedical sciences Glossary Further Reading
Specifications
Publisher
Oxford University Press
Publication date
August 26, 2010
Pages
256
ISBN
9780199565603
Format
Hardback

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