Human Virology

Viruses are some of the simplest infectious agents on the planet, yet can cause severe and even life-threatening diseases in all forms of life - including humans. Despite relying on host cells in order to replicate, viruses can be capable of extremely rapid reproduction and very effective transmission from one person to another. Because of this, they have historically represented a significant proportion of the disease burden affecting humans, in addition to a number of new high profile diseases which have emerged in the last century. However, on a more positive note, the only two diseases to have ever been eradicated by mankind were both viruses, giving hope that in the future more viruses can be eliminated.

Human Virology provides a vivid introduction to this fascinating field, by incorporating both the molecular and clinical aspects of the subject. The general principles and properties of viruses are covered in the first part of the text, while part two provides a survey of the different virus families and the human diseases they cause. Finally, the book concludes with some of the more practical aspects of the subject, such as immunization, antiviral chemotherapy and laboratory techniques.

Throughout the text, case studies bring the subject to life by providing a unique perspective from real practicing doctors. In addition new 'hot topic' boxes have been incorporated into this edition, featuring current important areas of research. Little prior knowledge is assumed, making Human Virology the perfect text for those students new to the subject.

The Online Resource Centre to accompany Human Virology features:

For students:
·multiple-choice questions for self-directed learning
·Web links to online animations and videos

For lecturers:
·Figures from the book in electronic format, ready to download

Table of Contents

Part 1: General principles
1: Virology: how it all began and where it will go
2: General properties of viruses
3: Viral replication and genetics
4: How viruses cause disease
5: Resistance of the human body to virus infections
6: Viruses and the community: the science and practice of epidemiology
Part 2: Specific viruses
Group 1 - Positive sense single stranded RNA viruses
7: Picornaviruses: polio, hepatitis A, and common cold
8: Astroviruses: gastroenteritis agents
9: Calciviruses: norovirus and gastroenteritis
10: Hepeviruses: hepatitis E
11: Togaviruses: mosquito borne, Chikungunya, Rubella, and a teratogen
12: Flaviviruses: mosquito borne, yellow fever, dengue, blood borne Hepatitis C
13: Coronaviruses: respiratory MERS, SARS
Group 2 - Negative sense single stranded RNA viruses
14: Myxoviruses: influenza A, B, C
15: Arenaviruses: Lassa and haemorrhagic fevers
16: Bunyaviruses: hanta, phlebo, and nairo viruses
17: Paramyxoviruses: respiratory syncytial virus, meta pneumo virus and emerging Hendra and Nipah
18: Filoviruses: zoonotic, Marburg, and Ebola
19: Rabies: zoonotic rabies
Group 3 - Double stranded RNA viruses
20: Reoviruses: rota and diarrhoea viruses
Group 4 - Double stranded DNA viruses
21: Polyomaviruses
22: Papillomaviruses: warts and cervical carcinoma
23: Herpes viruses: herpetic lesions, cancer, and encephalitis
24: Smallpox: human disease eradicated but zoonotic infections common
25: Adenovirus: respiratory, eye, and gastroenteritis viruses
Group 5 - Single stranded DNA viruses
26: Parvovirus: childhood rash, aplastic crisis, foetal infection
Group 6 - Single stranded positive sense RNA with an RT
27: Retroviruses: HIV 1 and 2 and HTLV
Group 7 - Circular double stranded DNA viruses with an RT
28: Hepadnaviruses: hepatitis B and D
Part 3: Practical aspects
29: The clinical virology laboratory: molecular techniques
30: Control of viral disease by immunisation
31: Antiviral chemotherapy

Leslie Collier, Emeritus Professor of Virology, University of London, John Oxford, Emeritus Professor of Virology, Queen Mary, University of London, and Paul Kellam, Virus Genomics team leader, Sanger Institute, Wellcome Trust

Leslie Collier was from 1978 to 1986 Professor of Virology at the London Hospital Medical College, being succeeded in this post by John Oxford.

John Oxford is Professor of Virology at St. Bartholomew's and The Royal London School of Medicine and Dentistry at the University of London. He is the co-author of two standard texts on Influenza and Virology and has published 250 scientific papers throughout the world. Professor Oxford serves as the Scientific Director of hVIVO Ltd., the College's research virology company.

Paul Kellam is Virus Genomics Team Leader at the Sanger Institute, Cambridge, and Reader in Host & Pathogen Interactions in the Department of Infection, MRC Centre for Medical Molecular Virology, University College London.